The Eastern Siberia region is a Siberian macroregion that unites the territories of several subjects of Russia (Novosibirsk and Irkutsk regions, Krasnoyarsk Krai) and is part of the VATRUS territorial structure of the VATSIM international network.

The Eastern Siberia region includes Novosibirsk ACC, Krasnoyarsk ACC and Irkutsk ACC, which together cover the airspace over the territory of the Siberian Federal District with a total area of more than 5 million km. More than a 10 international airports are located on the territory of the macroregion. There are a trans-Siberian routes in the upper airspace of Novosibirsk ACC and Krasnoyarsk ACC. It provides a transit flow of aircraft from Europe and North America to Asia and back. Air routes connect the airspace of Russia with the airspace of Mongolia, China and Kazakhstan.

In the VATSIM network the air traffic service over the territory of the macroregion is carried out by the position RU-ESC_FSS, callsign "Siberia-Control", frequency 135.225.